• The Venerable Pierre Toussaint - A former slave from the French colony of Saint-Domingue He became a noted philanthropist to the poor of the city. Due to his devout and exemplary life, the Catholic Church has been investigating his life for possible canonization and in 1996 he was declared "Venerable" by Pope John Paul II, the second step in the process. Toussiant’s remains were moved from the North Cemetery of St. Patrick’s Old Cathedral to the crypt below the main altar of St. Patrick's Cathedral on Fifth Avenue in the late 20^th century. He is the first layperson to be buried in this special place normally reserved for bishops of the Roman Catholic Archdiocese of New York.
• Andrew Morris - First Roman Catholic elected to public office in New York City or New York State - served as Assistant Alderman of New York's First Ward, and also served in the New York State Assembly - Irish immigrant - founding Trustee of St. Peter's Church and St. Patrick's (Old) Cathedral. He served on the Building Committee of the Cathedral, and was a major contributor of funds for the building of both St. Peter's and St. Patrick's. Purchased (along with Cornelius Heeney) the property on which the "new" St. Patrick's Cathedral was built. - Buried in unmarked grave in Churchyard cemetery.
• Francis Delmonico and the Delmonico Family - Founders of the Hospitality Industry in New York City and proprietor of one of New York’s first fine dining establishments who catered to the likes of Mark Twain as well as many other prominent New Yorkers is buried in catacombs.
• Francis Cooper - First Roman Catholic elected to New York State Assembly - his election forced the changing of state law in 1803, forbidding Catholics from holding public office in New York State. Buried in Churchyard Cemetery
• Charles O'Connor - U.S. Presidential candidate, 1872 - noted attorney - Legal Counsel for the Archdiocese of New York - buried in the catacombs, but a large O'Connor cenotaph is present in the Churchyard cemetery
• Thomas O'Connor - Charles' father - journalist - Editor of New York's first Irish newspaper, The Shamrock - also buried in the catacombs -
• John Michael O'Connor - Captain, U.S. Army Artillery, War of 1812 - buried in O'Connor crypt
• "Honest" John Kelly - Member of U.S. House of Representatives, City Sheriff, Tammany Hall leader - buried in the catacombs.  Learn more about "Honest" John Kelly by clicking on this link
• John McKeon - U.S. Attorney General for the Southern District of New York - member of U.S. House of Representatives - New York County District Attorney - buried in the catacombs
• James McKeon - Captain of US Artillery, War of 1812 - John McKeon's father - also buried in the catacombs
• Thomas T. Eckert - Brevet Brigadier General, U.S. Telegraphy Corps, American Civil War - Close personal friend and confidant of President Abraham Lincoln – Lincoln drafted the emancipation proclamation in the General’s office. Became president of Western Union Company after the war - buried in the catacombs whose crypt still boasts working Edison light bulbs
• John R. Brady - Attorney, Justice of New York Supreme Court - Administered Oath of Office to President Chester A. Arthur - Son of Thomas Brady, Educator - Brother of James Topham Brady, noted defense attorney of New York. - buried in the catacombs
• Thomas Brady - Attorney and Educator - Tutored future Cardinal John McCloskey in Latin - father of James T. and John R. Brady
• James Topham Brady - Noted Criminal Defense Attorney - Candidate for Governor of New York - son of Thomas Brady and brother of Judge John R. Brady - buried in the catacombs
• Gregory Dillon - Founding President of the Emigrant Industrial Savings Bank - Captain in U.S. Army, War of 1812, co-founder of the Irish Emigrant Society - Irish immigrant, appointed Commissioner of Emigration of New York State - buried in Churchyard cemetery
• Andrew Carrigan - A founding officer of the Emigrant Industrial Savings Bank, and Commissioner of Emigration of New York State - President of Irish Emigrant Society - Irish immigrant - buried in the catacombs
• Charlotte Melmoth - Noted Shakespearean stage actor of the 18th and early 19th century, largely known for her performance as Lady Macbeth - she was a personal friend of Benjamin Franklin - in her later years, after giving up stage acting in 1812, she taught English elocution (John McCloskey, future Cardinal of New York, was a student of hers) and she also ran a boarding house and school in Red Hook, Brooklyn, which many children of the most prominent Brooklyn families attended. - She is buried in an unmarked grave in the Churchyard cemetery
• Captain Pierre de Landais - Captain of the U.S. Navy in The Revolutionary War, originally a Rear-Admiral in the French Navy, he was an associate of General Lafayette of American Revolutionary War fame - he fought along with John Paul Jones in the capture of the British ship Serapis, but was accused of insubordination and near treasonous sabotage of Jones' efforts. For this reason, he was never awarded a pension by the U.S. Congress, and he was forced to resign from the French and American Navy as a result. He protested until his death that he was innocent of the charges against him. - buried in the Churchyard cemetery, location is in question.
• Stephen Jumel - French merchant and planter who immigrated to America from Saint Domingue (later re-named Haiti) during the Slave Revolt in the 1790's - he purchased the Morris-Jumel Mansion which still stands today in upper Manhattan. Was first husband of Eliza Jumel, socialite, who later married Aaron Burr, former U.S. Vice-President. - Stephen Jumel is buried in the Churchyard cemetery
• Captain Joseph Lametti - Captain in the U.S. Army 9th Artillery in the War of 1812 - Italian immigrant from the city of Modena. - had a memorial plaque placed at his grave in 1930 by the General Society of The War of 1812 in a large ceremony, but it has been missing from the gravesite for many years - buried in the Churchyard cemetery.
• Countess Anna Leary - Philanthropist and financier, particularly for the Italian children who were arriving in New York City in the later 19th century. She financed the building of the Chapel at Bellevue Hospital - the title of Countess was granted to her by Pope Leo as a reward for her charitable works - she is buried in the catacombs with her parents and siblings, one of whom was the noted banker, Arthur Leary.
• Dominick Lynch and the Lynch Family - Dominick Lynch senior was a wealthy merchant and an Irish immigrant - he was a founding trustee of St. Peter's and (Old) St. Patrick's Cathedral in New York City - he attended the inauguration of George Washington in New York, and also was a signatory to the Address of Congratulations to the newly-inaugurated President Washington by The Roman Catholic community of America. He along with Lorenzo Da Ponte brought Italian Opera to New York City. Lynch owned the town of Lynchville in New York State, which was later re-named Rome, New York. Lynch senior was an early member of the Friendly Sons of St. Patrick in New York - The Lynch Family is buried in the catacombs
• Dominick Lynch II - was a wealthy merchant and importer of Chateau Margaux, Lynch Sauterne, and Lynch's Lucca Oil. He also was a great supporter of the Arts, and he financed the first Italian Opera company (The Garcia Troupe) ever to perform in New York. He was regularly called "the most fashionable man in New York" by his contemporaries.
• Valentine Derry - Exiled from Ireland for his participation in the United Irishmen's Rebellion in 1798 - became a teacher of the Classics at Erasmus Hall School in Flatbush, Brooklyn in 1808 - he later opened his own Academy in Newtown, Queens County - buried in Churchyard cemetery.
• Charles DelVecchio - Officer in the first Roman Catholic Benevolent Society of New York in 1816 - Also a generous supporter of the Roman Catholic Orphan Asylum in 1817 - Trustee of St. Patrick's Old Cathedral - buried in Churchyard cemetery.
• Col. James R. Mullany and Family - Veteran of the War of 1812 - Held the office of quartermaster general in the United States Army, 1816-1818.
• John B. LaSala - Benefactor of the first Orphan Society organization in New York - saved the first Visitation Convent in Georgetown, D.C. from closing by sending his daughters to attend in 1822, thereby funding the convent until it became solvent - Member of the "Friends of Freedom of Education" Carroll Hall group that met and ran candidates in November 1841 for the New York State Senate - buried in Churchyard cemetery.
• Patrick Nealis - Veteran of the American Revolutionary War - buried in Churchyard cemetery
• Dr. Robert W. Hogan - Founding member of the Irish Emigrant Society - long-time member and three term President of The Friendly Sons of St. Patrick in New York - buried in the catacombs.
• Peter Harmony - Wealthy merchant of Spanish ancestry, and owner of cotton mills - owner of Harmony Mills in Cohoes, New York, whose buildings still stand to this day - Also owned The Harmony House meeting place in NYC - buried in the catacombs.
• Edmund Fitzgerald - Alderman, New York Common Council - buried in the catacombs.
• Neva Hecker Sadlier - prolific Catholic Author and member of the Sadlier publishing family, which is still in business - buried in catacombs.
• John G. Gottsberger & Family - Merchant, wholesaler in wines & liquors, and distiller of cordials. - Member of the "Friends of Freedom of Education" Carroll Hall group that met and ran candidates in November 1841 for the New York State Senate - Ran for State Senate in New York on Bishop Hughes' "Carroll Hall" ticket during the Public School controversy in 1841 - Buried in large underground family vault in Churchyard cemetery.
• James Hart - Veteran of the War of 1812 - served for fifty years as Sexton of St. Patrick's Churchyard cemetery, the Eleventh Street Cemetery, and Calvary Cemetery - Irish immigrant, and close personal friend of Archbishop John Hughes - originally buried in the Churchyard cemetery, and later moved to a crypt in the catacombs where his son is also buried.
• Daniel Keeline - One of the original 22 Catholics who petioned the French Consulate to open the first Catholic Church in New York City; St. Peter's. Buried in the North Cemetery.

And Many More!